Association of RNA polymerase III antibodies with scleroderma renal crisis.
نویسندگان
چکیده
منابع مشابه
Autoantibodies to RNA-polymerases in Italian patients with systemic sclerosis.
OBJECTIVE To assess the frequency and clinical correlates of the systemic sclerosis-related autoantibodies to RNA polymerases in Italian patients. METHODS Sera from 115 patients with systemic sclerosis (SSc) and 10 patients with systemic sclerosis-overlap syndromes recruited from a single center in northern Italy were investigated for antibodies to RNA polymerase I, II, and III by means of im...
متن کاملA Case of Renal Crisis in a Korean Scleroderma Patient with Anti-RNA polymerase I and III Antibodies
Scleroderma (SSc) renal crisis has been reported to be associated with anti-RNA polymerase I and III (RNAP I/III) antibodies in Caucasians and the Japanese. However, no report is available for Korean SSc patients. Here, we describe the case of a 65-yr-old female SSc patient who developed renal crisis and whose serum contained anti-RNAP I/III antibodies. She was finally diagnosed as having diffu...
متن کاملA longitudinal study of anti-RNA polymerase III antibody levels in systemic sclerosis.
OBJECTIVES Anti-RNA-polymerase antibodies (ARAs) are associated with the diffuse cutaneous subset of SSc (dcSSc) and particularly with scleroderma renal crisis (SRC). We analysed serial ARA levels and explored the relationship with clinical features and disease outcome. METHODS A commercially available ELISA method with a recombinant peptide of RNA polymerase III was used and ARA levels were ...
متن کاملA Unique Presentation of Anti-RNA Polymerase III Positive Systemic Sclerosis Sine Scleroderma
Systemic sclerosis is a rare autoimmune disorder with a wide spectrum of clinical manifestations and a multitude of autoantibodies that are associated with it. In the past several years, advances in serologic testing have led to research indicating important prognostic and phenotypic associations with certain subsets of autoantibodies. In particular, anti-RNA polymerase III (anti-RNAP III) has ...
متن کاملRenal complications and scleroderma renal crisis.
Scleroderma renal crisis (SRC) occurs in 5-10% of SSc patients, who may present with an abrupt onset of hypertension, acute renal failure, headaches, fevers, malaise, hypertensive retinopathy, encephalopathy and pulmonary oedema. Patients at greatest risk of developing SRC are those with diffuse cutaneous or rapidly progressive forms of SSc, and treatment with a recently commenced high dose of ...
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ورودعنوان ژورنال:
- The Journal of rheumatology
دوره 37 5 شماره
صفحات -
تاریخ انتشار 2010